Cailin Conner

Urban Health Today

Despite a growing interest, large-scale studies comparing remnant cholesterol (RC) with other lipid parameters in relation to diabetes and prediabetes remain limited. Therefore, a team of investigators sought &ldquo;to discover the relationship between RC and prediabetes, diabetes, and insulin resistance (IR) and to investigate RC, high-density lipoprotein cholesterol (HDL-C), non&ndash;HDL-C, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C, which are the lipid parameters that are most positively related to diabetes, prediabetes, and IR.&rdquo;The multicenter, large sample survey, published in the Journal of Diabetes, consisted of 36,684 participants. While controlling for potential confounders, investigators employed multiple logistic regression analysis to examine the association between different lipid parameters and the likelihood of diabetes, prediabetes, and IR.The results of the study showed that RC had the most substantial positive association with diabetes, prediabetes, and IR among the lipid parameters assessed. Specifically, the odds ratios (ORs) for diabetes, prediabetes, and IR with respect to RC were 1.417 (95% CI, 1.345-1.492), 1.555 (95% CI, 1.438-1.628), and 1.488 (95% CI, 1.404-1.577), respectively.Furthermore, the association between RC and these metabolic conditions remained significant even when conventional lipid levels were within typical ranges. For example, when triglycerides (TG) were below 2.3 mmol/L, the ORs for diabetes, prediabetes, and IR were 1.256 (95% CI, 1.135-1.390), 1.503 (95% CI, 1.342-1.684), and 1.278 (95% CI, 1.140-1.433), respectively. Similarly, with LDL-C levels below 2.6 mmol/L, the ORs were 1.306 (95% CI, 1.203-1.418) for diabetes, 1.597 (95% CI, 1.418-1.798) for prediabetes, and 1.552 (95% CI, 1.416-1.701) for IR. When HDL-C was &ge;1 mmol/L, the ORs were 1.456 (95% CI, 1.366-1.550) for diabetes, 1.553 (95% CI, 1.421-1.697) for prediabetes, and 1.490 (95% CI, 1.389-1.598) for IR.&ldquo;RC is more positively related to diabetes, prediabetes, and IR than conventional lipids and lipid ratios in the general population,&rdquo; the investigators wrote. &ldquo;RC could be calculated easily using the formula and is of clinical relevance, and we recommend that health care professionals consider RC as one of the major objectives of lipid management.&rdquo;Source: <a href="https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.13592" target="_blank" rel="noopener">Journal of Diabetes</a>

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Remnant Cholesterol More Strongly Associated With Diabetes, Insulin Resistance Than Traditional Lipids

Remnant cholesterol has a stronger and more consistent association with diabetes, prediabetes, and insulin resistance compared with traditional lipid parameters.

Remnant Cholesterol More Strongly Associated With Diabetes, Insulin Resistance Than Traditional Lipi

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